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雷海新


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雷海新博士,大连医科大学肿瘤干细胞研究院教授,常务副院长,博士生导师。主要从事基因表达调控、长链非编码RNA与肿瘤发生以及RNA定位机制研究。在Nucleic Acids Res (IF:11.1), J Natl Cancer Inst (IF:10.2), Proc Natl Acad Sci USA (IF:9.58), Nat Commun, Clin Chem, Mol Cell Biol, Int J Cancer, Cell Death&Dis, RNA Biol以及 Carcinogenesis等学术期刊上发表20余篇论文,总影响因子172, 引用上千次。
学习经历:
2000 – 2004: 瑞典卡洛琳斯卡医学研究所分子流行病学专业博士
1994 – 1997: 中国预防医学科学院劳动卫生与职业病研究所硕士
1990 – 1994: 四川大学生物工程系学士
科研工作经历
2012/12 – 至   今,大连医科大学,肿瘤中心肿瘤干细胞研究院,教授
2006/03 – 2012/11,美国哈佛大学,医学院细胞生物学系,博士后
2005/03 – 2006/02,德国癌症研究中心(海德堡),客座科学家
2002/11 – 2005/01,英国南安普敦大学,医学院人类遗传系,科研助理
1997/07 – 1999/12,中国科学院生物物理研究所,助理研究员
主要学术任职:
中国生化与分子生物学会RNA专业委员会理事
中国抗癌协会整合肿瘤分会委员
中国抗癌协会肿瘤标志物委员会委员
中国病理生理学会免疫专业委员会
国际RNA Society会员
联系方式:
电话:0411-86110494  E-mail: haixinlei@dmu.edu.cn
代表性论文:
  1. Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang L, Lei H*. (2019) XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence. Nucleic Acids Res. 47(15): 8239-8254. (IF: 11.147)

  2. Azam S, Hou S, Zhu B, Wang W, Hao T, Bu X, Khan M, Lei H*. (2019) Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus. RNA Biol. 16(8):1001-1009. (IF: 5.477)

  3. Shuai Hou, Na Li, Qian Zhang, Hui Li, Xinyue Wei, Tian Hao, Yue Li, Sikandar Azam, Caigang Liu, Wei Cheng, Bilian Jin, Quentin Liu, Man Li, and Haixin Lei*. (2016) XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE. Cell Death and Disease 7, e2409. (IF: 5.959; cited: 11)

  4. Shuai Hou, Lei Shi, and Haixin Lei*. (2016) Biotin-streptavidin affinity purification of RNA-protein complexes assembled in vitro. Methods Mol Biol. 1421:23-34.

  5. Hui Li, Shuai Hou, Tian Hao, Sikandar Azam, Caigang Liu, Lei Shi, and Haixin Lei*. (2015) HuR antagonizes the effect of an intronic pyrimidine-rich sequence in regulating WT1 +/-KTS isoforms. RNA Biol.

  6. Lei H, Zhai B, Yin S, Gygi S, Reed R. (2013) Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export. Nucleic Acids Res. 41(4):2517-25. (IF: 11.147; cited: 65)

  7. Lei H, Dias AP, Reed R. Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex. Proc Natl Acad Sci USA. 108(44):17985-90, 2011. (IF: 9.58; cited: 71)

  8. Haixin Lei, Kari Hemminki, Robert Johansson, Andrea Altieri, Kerstin Enquist, Roger Henriksson, Per Lenner and Asta Försti. (2008) PAI-1 -675 4G/5G polymorphism as a prognostic biomarker in breast cancer.  Breast Cancer Res Treat. 109(1):165-75. (IF: 3.471; cited: 39)

  9. Haixin Lei, Kari Hemminki, Andrea Altieri, Robert Johansson, Kerstin Enquist, Göran Hollmans, Per Lenner and Asta Försti. (2007) Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. Breast Cancer Res Treat. 103(1):61-9. (IF: 3.471; cited: 77)

  10. Haixin Lei, Ian Day and Igor Vorechovsky. (2005) Exonization of Alu Ya5 in the human ACE gene requires at least two point mutations and is facilitated by a conserved splicing enhancer. Nucleic Acids Res. 33 (12): 3897-906. (IF: 11.147; cited: 33)

  11. Haixin Lei and Igor Vorechovsky. (2005) Identification of splicing silencers and enhancers in sense Alus: a role for pseudo-acceptors in splice site repression. Mol Cell Biol. 25 (16): 6912-20. (IF: 3.735; cited: 36)

  12. Haixin Lei, Igor Vorechovsky. (2003) BACH1 517C→T transition impairs protein translocation to nucleus: a role in breast cancer susceptibility?  Int J Cancer. 104(3): 389-91. (IF: 4.982; cited: 12)

  13. Haixin Lei, Daria Pospisilova, Annica Lindblom and Igor Vorechovsky. (2002) Re: Dominant negative ATM mutations in breast cancer families.  J Natl Cancer Inst. 94(12):951-2. (IF: 10.211; cited: 10)

  14. Haixin Lei, Jan Zaloudik, Igor Vorechovsky. (2002) Lack of association of the -1171 (5A) allele of the MMP3 promoter with breast cancer.  Clin Chem. 48(5): 798-9. (IF: 6.891; cited: 29)

  15. Liping Luo*, Haixin Lei*, Quan Du, Anna von Wachenfeldt, Ingrid Kockum, Holger Luthman, Igor Vorechovsky and Annica Lindblom. (2002) No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22. Int J Cancer. 98(4): 638-9. (IF: 4.982; cited: 39)

  16. Haixin Lei, Sara Sjoberg-Margolin, Sima Salahshor, Barbro Werelius, Eva Jandakova, Kari Hemminki, Annica Lindblom and Igor Vorechovsky. (2002) CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk. Int J Cancer. 98(2):199-204. (IF: 4.982; cited: 87)

 

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联系电话:86110509
辽宁大连旅顺南路西段9号 大连医科大学
联系电话:86110509