韩传春-肿瘤干细胞研究院

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韩传春

韩传春，教授，博士生导师，2013年毕业于中国科学技术大学细胞生物学专业主要致力于肿瘤发生的分子机制研究，特别是泛素化修饰和长链非编码RNA在肿瘤发生发展中的作用。以通讯作者或第一作者身份在Nature Communications（2019 IF 12.121）、Cell death and differentiation（2020 IF 15.828）、Cancer Letters (IF 6.549)、STEM CELLS（IF 7.701）等发表论文20篇，其中JCR一区论文17篇，中科院分区一区论文8篇，总影响因子大于110。

现任辽宁省细胞生物学会神经生物学分会理事；辽宁省细胞生物学学会肿瘤免疫学和免疫治疗专业分会理事；Cancer Letters、J Exp Clin Cancer Res等杂志特邀审稿；国家基金委面上和青年项目初审评议人（医学口）。

主持课题

国家级课题

1）项目名称及编号：去泛素化酶OTUD1负调控c-Myc介导糖代谢重编程抑制肺癌发生的分子机制研究，202001-202412，82073070；57万主持。

2）项目名称及编号：去泛素化酶USP17通过上调KLF4蛋白稳定性促进黑色素瘤适应代谢压力的分子机制研究，201901-202212 81874136；58万主持。

3）项目名称及编号：异柠檬酸脱氢酶1（IDH1）在黑色素瘤适应内质网应激中的作用和分子机制，201401-201712 81402260；23万主持。

省部级课题

1）项目名称及编号：CHOP和C/EBPβ调控IDH1促进黑色素瘤适应内质网压力的分子机制研究，201506-201706 2015020309；5万主持。

2）辽宁省高等学校创新人才，202011-202212，10万主持。

代表性论文(以第一作者或通讯作者；^#为第一作者，^*为通讯作者)

1)Xingyun Wang^#, Shilin Xia^#, Hongchang Li^#, Xiang Wang^#, Chaonan Li, Yulin Chao, Lingqiang Zhang^4*&Chuanchun Han^*The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis. Cell Death and Differentiation, 2020（IF 15.828）（通讯作者）

Tongde Du^#, Hongchang Li^#, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui,Chuanchun Han^*& Lingqiang Zhang^*.The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis. Nature Communications,(2019) 10:2914.（IF 12.121）（通讯作者）
Jingrong Lin^#, Dongmei Zhang^#, Yongsheng Fan^#, Yulin Chao¹, Jinming Chang, Na Li, Linlin Han,Chuanchun Han^*Regulation of cancer stem cell self-renewal by HOXB9 antagonizes ER stress-induced melanoma cell apoptosis via the miR-765-FOXA2 axis. 2018,Journal of investigative dermatology (IF 6.287)（通讯作者）
Dongmei Zhang^＃, Binbin Ma^＃, Yulin Chao^＃, Lei Jin, Na Li, Ruiping He, Wenzhi Zhao,Chuanchun Han^*.Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression. J Exp Clin Cancer Res. 2018; 37: 176（IF 6.217）。（通讯作者）
Xuejun Yang^＃, Dongmei Zhang^＃, Sha Liu^＃, Xiaojie Li, Wanglai Hu,Chuanchun Han^*KLF4 suppresses the migration of hepatocellular carcinoma by transcriptionally upregulating monoglyceride lipase Am J Cancer Res. 2018; 8(6): 1019–1029.（IF 4.737）（通讯作者）
Xiaojie Li^#, Changhong Ma^#, Li Zhang^#, Na Li, Xiaohong Zhang, Jianya He, Ruiping He, Miaomiao, Shao, Junling Wang, Lan Kang^*,Chuanchun Han^*LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expressionCancer Letters2017 Oct 28;407:45-56.(IF6.375)(通讯作者)
Xuejun Yang^#, Tongde Du^#, XiangWang, Yingqiu Zhang, Wanglai Hu, Xiaofeng Du, Lin Miao^*,Chuanchun Han^*IDH1, a CHOP and C/EBPβ-responsive gene under ER stress, sensitizes human melanoma cells to hypoxia-induced apoptosis. Cancer Letters (2015) 10.106 (IF 5.992) (通讯作者)
Dongmei Zhang^#, Liang Zhu , Chunmei Li, Jingzhou Mu,Yuanshan Fu, Qiong Zhu,ZhenZhen Zhou,Pixu Liu,^*Chuanchun Han^*,Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction. Basic Res Cardiol (2015) 110:28（IF6.038）（通讯作者）
Xiaoying Yan^#, Ran Zhao, Xiaorong Feng, Jingzhou Mu, Ying Li, Yue Chen, Chunmei Li, Qiying Yao, Lijie Cai, Lingling Jin,Chuanchun Han*, and Dongmei Zhang* Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1a-TAK1 signalling pathway. Cardiovasc Res. 2020 Jan. (IF 10.787)（通讯作者）
Lu Zhang^#, Yuan Wang^#, Xiaojie Li^#, Yulin Chao, Ruiping He,Chuanchun Han^*, Wenzhi Zhao^*.ZBTB7A, a miR-663a target gene, protects osteosarcoma from endoplasmic reticulum stress-induced apoptosis by suppressing LncRNA GAS5 expression. Cancer Letters,448(2019) 105-116.（IF 7.36）（通讯作者）
Binbin Ma^#, Li Zhang^#, Yujie Zou^#, Ruping He, Qiong Wu ,Chuanchun Han^*, Bo Zhang^*.Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits. 2019,38:32.Journal of Experimental & Clinical Cancer Research（IF 7.068）（通讯作者）
Wenjing Qi^#, Chengsun Gao^#, Li Zhang^#, Zhenming Gao, Jidong Sui,Chuanchun Han^*, Deguang Sun^*MiR-3196, a p53-responsive microRNA, functions as a tumor suppressor inhepatocellular carcinoma by targeting FOXP4.American Journal of Cancer Research2019; 9(12): 2665.（IF 5.177）（通讯作者）
Binbin Ma^#，Zhongbo Yuan^#，Li Zhang , Peng Lv , Ting Yang , Jinxia Gao , Ning Pan , Qiong Wu ,Chuanchun Han^*, Bo Zhang^*Long non-coding RNA AC023115.3 suppresses glioblastoma chemoresistance by reducing autophagy.BBA- Molecular Cell Research Volume 1864, Issue 8, August 2017, Pages 1393–1404 (IF 4.5) (通讯作者)
Lu Zhang^#, Yuan Wang^#,Xiaojie Li^#, Xin Xia, Na Li, Ruiping He, Hongtao He,Chuanchun Han^*, Wenzhi Zhao^*ZBTB7A enhances osteosarcoma chemoresistance by transcriptionally repressing lncRNALINC00473–IL24 activityNeoplasia.2017 Nov;19(11):908-918 (IF5.006 )(通讯作者)

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